Aminocaproic acid
Aminocaproic Acid (aminocaproic acid) is a small molecule pharmaceutical. Aminocaproic acid was first approved as Amicar on 1982-01-01. The pharmaceutical is active against plasminogen.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
Amicar (generic drugs available since 1987-03-09)
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 28tak gum care tooth | unapproved drug other | 2018-07-17 |
| amicar | New Drug Application | 2022-06-28 |
| aminocaproic acid | ANDA | 2023-12-29 |
| bamboo salt eunganggo jook yeom | OTC monograph not final | 2011-03-16 |
| bamboo salt eunganggo jook yeom toothpaste | OTC monograph not final | 2010-06-21 |
| clean breath tooth | unapproved drug other | 2021-11-30 |
| dr.el gum care tooth | unapproved drug other | 2019-09-25 |
| dr.lord green propol tooth | unapproved drug other | 2022-04-06 |
| greensaltrain tooth | unapproved drug other | 2021-11-30 |
| hae yan tooth | unapproved drug other | 2020-05-29 |
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Indications
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Agency Specific
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HCPCS
Code | Description |
|---|---|
| S0017 | Injection, aminocaproic acid, 5 grams |
Clinical
Clinical Trials
36 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | 1 | 1 | 1 | 3 |
| Fibrinolysis | D005342 | — | — | — | 1 | 1 | 1 | 1 | 3 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | — | 1 | 2 | 3 |
| Scoliosis | D012600 | EFO_0004273 | M41 | — | — | — | 1 | 2 | 3 |
| Oral hemorrhage | D006472 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiopulmonary bypass | D002315 | — | — | — | 1 | 1 | — | 1 | 2 |
| Inflammation | D007249 | MP_0001845 | — | — | 1 | 1 | — | 1 | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 1 | — | — | 1 | 2 |
| Craniosynostoses | D003398 | HP_0005458 | Q75.0 | 1 | 1 | — | — | — | 2 |
| Surgical blood loss | D016063 | — | — | — | 1 | — | — | — | 1 |
| Thrombosis | D013927 | — | — | — | 1 | — | — | — | 1 |
| Hematologic neoplasms | D019337 | — | — | — | 1 | — | — | — | 1 |
| Thrombocytopenia | D013921 | HP_0001873 | D69.6 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cerebral hemorrhage | D002543 | — | — | 1 | — | — | — | — | 1 |
| Aortic diseases | D001018 | — | — | 1 | — | — | — | — | 1 |
| Rosacea | D012393 | — | L71 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | HP_0001635 | I50 | — | — | — | — | 2 | 2 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 2 | 2 |
| Menorrhagia | D008595 | EFO_0003945 | N92.0 | — | — | — | — | 2 | 2 |
| Hemophilia a | D006467 | EFO_0007267 | D66 | — | — | — | — | 2 | 2 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 2 | 2 |
| Pneumonia | D011014 | EFO_0003106 | — | — | — | — | — | 2 | 2 |
| Hyperaldosteronism | D006929 | HP_0011736 | E26 | — | — | — | — | 2 | 2 |
| Pulmonary arterial hypertension | D000081029 | — | — | — | — | — | — | 2 | 2 |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | — | — | — | 2 | 2 |
| Hypokalemia | D007008 | HP_0002900 | E87.6 | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Aminocaproic acid |
| INN | aminocaproic acid |
| Description | 6-aminohexanoic acid is an epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator. It has a role as an antifibrinolytic drug, a hematologic agent and a metabolite. It is an epsilon-amino acid and an omega-amino fatty acid. It is functionally related to a hexanoic acid. It is a conjugate acid of a 6-aminohexanoate. It is a tautomer of a 6-aminohexanoic acid zwitterion. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NCCCCCC(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 60-32-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1046 |
| ChEBI ID | 16586 |
| PubChem CID | 564 |
| DrugBank | DB00513 |
| UNII ID | U6F3787206 (ChemIDplus, GSRS) |
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Estimated US medical usage
Aminocaproic acid
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Trends
PubMed Central
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Additional graphs summarizing 9,302 documents
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Safety
Black-box Warning
Black-box warning for: Lisinopril
Adverse Events
Top Adverse Reactions
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177 adverse events reported
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