Aminocaproic acid
Amicar, Aminocaproic Acid (aminocaproic acid) is a small molecule pharmaceutical. Aminocaproic acid was first approved as Amicar on 1982-01-01. The pharmaceutical is active against plasminogen.
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Commercial
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Trade Name
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Amicar, Aminocaproic acid (discontinued: Amicar, Aminocaproic, Aminocaproic acid)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Aminocaproic acid
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| AMICAR | Hikma Pharmaceuticals | N-015197 RX | 1982-01-01 | 2 products, RLD |
| AMICAR | Hikma Pharmaceuticals | N-015230 RX | 1982-01-01 | 1 products, RLD |
Show 2 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 28tak gum care tooth | unapproved drug other | 2018-07-17 |
| amicar | New Drug Application | 2022-06-28 |
| aminocaproic acid | ANDA | 2025-08-14 |
| bamboo salt eunganggo jook yeom toothpaste | OTC monograph not final | 2010-06-21 |
| clean breath tooth | unapproved drug other | 2021-11-30 |
| dr.lord green propol tooth | unapproved drug other | 2022-04-06 |
| greensaltrain tooth | unapproved drug other | 2021-11-30 |
| hae yan tooth | unapproved drug other | 2020-05-29 |
| hea yantoothpaste | unapproved drug other | 2023-04-23 |
| himangchantoothpaste | unapproved drug other | 2021-04-12 |
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Indications
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Agency Specific
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Patent Expiration
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HCPCS
Code | Description |
|---|---|
| S0017 | Injection, aminocaproic acid, 5 grams |
Clinical
Clinical Trials
37 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemorrhage | D006470 | MP_0001914 | R58 | — | 2 | 1 | 4 | 6 | 13 |
| Fibrinolysis | D005342 | — | — | — | 1 | 1 | 1 | 2 | 4 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | — | 1 | 3 | 4 |
| Cardiopulmonary bypass | D002315 | — | — | — | 1 | 1 | 1 | 1 | 3 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 1 | — | 1 | 1 | 3 |
| Scoliosis | D012600 | EFO_0004273 | M41 | — | — | — | 1 | 2 | 3 |
| Joint diseases | D007592 | — | M12.9 | — | — | — | 1 | 1 | 2 |
| Oral hemorrhage | D006472 | — | — | — | — | — | 1 | — | 1 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | — | — | 1 | — | 1 |
| Rheumatic diseases | D012216 | — | M79.0 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Inflammation | D007249 | MP_0001845 | — | — | 1 | 1 | — | 1 | 2 |
| Gingivitis | D005891 | — | K05.10 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thrombocytopenia | D013921 | HP_0001873 | D69.6 | — | 1 | — | — | 1 | 2 |
| Craniosynostoses | D003398 | — | Q75.0 | 1 | 1 | — | — | — | 2 |
| Surgical blood loss | D016063 | — | — | — | 1 | — | — | — | 1 |
| Thrombosis | D013927 | — | — | — | 1 | — | — | — | 1 |
| Transfusion reaction | D065227 | — | D69.51 | — | 1 | — | — | — | 1 |
| Hematologic neoplasms | D019337 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cerebral hemorrhage | D002543 | — | — | 1 | — | — | — | 2 | 3 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 1 | — | — | — | — | 1 |
| Aortic diseases | D001018 | — | — | 1 | — | — | — | — | 1 |
| Rosacea | D012393 | — | L71 | 1 | — | — | — | — | 1 |
| Skin diseases | D012871 | — | L00-L99 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | EFO_0003144 | I50 | — | — | — | — | 2 | 2 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 2 | 2 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | — | 2 | 2 |
| Menorrhagia | D008595 | EFO_0003945 | N92.0 | — | — | — | — | 2 | 2 |
| Hemophilia a | D006467 | EFO_0007267 | D66 | — | — | — | — | 2 | 2 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 2 | 2 |
| Pneumonia | D011014 | EFO_0003106 | J18 | — | — | — | — | 2 | 2 |
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | — | — | — | — | 2 | 2 |
| Hyperaldosteronism | D006929 | — | E26 | — | — | — | — | 2 | 2 |
| Pulmonary arterial hypertension | D000081029 | — | — | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Aminocaproic acid |
| INN | aminocaproic acid |
| Description | 6-aminohexanoic acid is an epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator. It has a role as an antifibrinolytic drug, a hematologic agent and a metabolite. It is an epsilon-amino acid and an omega-amino fatty acid. It is functionally related to a hexanoic acid. It is a conjugate acid of a 6-aminohexanoate. It is a tautomer of a 6-aminohexanoic acid zwitterion. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NCCCCCC(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 60-32-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1046 |
| ChEBI ID | 16586 |
| PubChem CID | 564 |
| DrugBank | DB00513 |
| UNII ID | U6F3787206 (ChemIDplus, GSRS) |
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Aminocaproic acid
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Safety
Black-box Warning
Black-box warning for: Lisinopril
Adverse Events
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236 adverse events reported
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